(一)科研项目:
1. 国家自然科学基金青年基金项目,基于肠道菌群胆汁酸代谢途径探究熊去氧胆酸调控猪流行性腹泻病毒感染的作用及机制,2024.01-2026.12,主持; 2. 沙河高教园高校成果概念验证项目,猪流行性腹泻减酶活疫苗的研发及产业化应用,2026.01-2027.12,主持; 3. 北京农学院,农业领域科技创新“火花行动”支持计划,熊去氧胆酸调控仔猪产肠毒素大肠杆菌感染的作用及机制研究, 2023.10-2025.10,主持。
(二)代表论文:
1. He Z, Guo N, Yu C, et al. Gut microbiota remodeling by Astragalus membranaceus stems and leaves correlates dual modulation of arachidonic acid and tryptophan metabolism to counteract perinatal stress-induced hemometabolic dysregulation in sows. Anim Microbiome. 2026;8(1):21. (1区IF2025=4.4) 2. Lv Y, Zhou Y, Lu H, Dong H and He Z*. Determinants of piglet gut microbiome colonization: Roles of genetics, Nutrition, Therapeutics, and the impact of Enteric Pathogens like PEDV. Front. Cell. Infect. Microbiol. 2025; 1626239. (2区IF2024=4.8) 3. Lu H, Liu H, Guo N, Zhou Y, Lu H, He Z* and Dong H*. Saxifraga stolonifera inhibits porcine epidemic diarrhea virus infection by disrupting nucleocapsid protein-p53 interaction. Front. Cell. Infect. Microbiol. 2025; 14615300. (2区IF2024=4.8) 4. Liu H, Lu H, Wang Y, Yu C, He Z*, Dong H*. The roles of short-chain fatty acids derived from colonic bacteria fermentation of non-digestible carbohydrates in ameliorating intestinal mucosal immunity of young ruminants. Front. Cell. Infect. Microbiol. 2024; 1449030. (2区IF2023=4.6) 5. He Z, Dong H*. The roles of short-chain fatty acids derived from colonic bacteria fermentation of non-digestible carbohydrates in ameliorating intestinal mucosal immunity of young ruminants. Front. Immuno. 2023; 1291846. (1区IF2022=7.3) 6. He Z#, Ma Y#, Yang S, et al. Gut microbiota-derived ursodeoxycholic acid from neonatal dairy calves improves intestinal homeostasis and colitis to attenuate extended spectrum β-lactamase producing enteroaggregative Escherichia coli infection. Microbiome; 10,79(2022). (1区IF2021=16.837) 7. He Z#, Ma Y#, Chen X, et al. Protective Effects of Intestinal Gallic Acid in Neonatal Dairy Calves Against Extended-Spectrum β-lactamase Producing Enteroaggregative Escherichia coli Infection: Modulating Intestinal Homeostasis and Colitis. Front. Nutr. 2022; 9:864080. (1区IF2021=6.590) 8. He Z, Ma Y, Chen X, et al. Temporal Changes of Fecal Unabsorbed Carbohydrates Relative to Perturbations in Gut Microbiome of Neonatal Calves: Emerging of Diarrhea Induced by Extended-Spectrum β-lactamase Producing Enteroaggregative Escherichia coli. Front. Microbiol. 2022; 13: 883090 (2区IF2021=6.064) 9. He Z, Yang S, Ma Y, et al. Detection of CTX-M-15 Extended-Spectrum β-Lactamases Producing Escherichia coli Isolates from Colostrum and Faeces of Newborn Dairy Calves in China. Pathogens. 2021 Sep 9;10(9). (2区IF2021=4.531) 10. He Z, Chen X, Fu M, et al. (2019). Inhibition of fowl adenovirus serotype 4 replication in Leghorn male hepatoma cells by SP600125 via blocking JNK MAPK pathway. Veterinary microbiology, 228, 45–52. (1区IF2019=3.029)
(三)代表著作
1.普通高等教育“十四五”国家重点出版物-《兽用中药现代应用研究》.中国农业大学出版社,2025.06.
(四)授权专利
1. 吕彦卓; 何至远; 董虹; 芦烘德; 邹桐; APPLICATION OF URSODEOXYCHOLIC ACID IN THE PREPARATION OF DRUGS FOR THE PREVENTION AND TREATMENT OF VIRAL DIARRHEAL DISEASE, 2025-12-12, 欧洲, NP-GRANT-LU602049; 2. 熊去氧胆酸在制备大肠杆菌性腹泻病防治药物中的应用,(ZL202111460070.1),曹志军,何至远等; 3. 腹泻性大肠杆菌感染动物模型的构建方法及其应用,(ZL202111460757.5),曹志军,何至远等; 4.一种嵌合病毒样颗粒疫苗及其制备方法和应用,(ZL202010442401.8),何至远,张贺楠等。
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